Treating A Patient With Sepsis And Full Thickness Necrosis

Start Page: 28
34
Author(s): 
Kristine Hoffman, DPM

5. Childers BJ, Cobanov B. Acute infections purpura fulminans: a 15-year retrospective review of 28 consecutive cases. Am Surg. 2003; 69(1):86-90.

6. Nolan J, Sinclair R. Review of management of purpura fulminans and two case reports. Br J Anaesth. 2001; 86(4):581-586.

7. Darmstadt GL. Acute infectious purpura fulminans: pathogenesis and medical management. Ped Dermatol. 1998; 15(3):169-83.

8. Francis RB. Acquired purpura fulminans. Semin Thromb Haemostat. 1990; 16(4):310-25.

9. Faust SN, Levin M, Harrison OB, Goldin RD, et al. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med. 2001; 345(6):408-416.

10. Kravitz GR, Dries DJ, Peterson ML, Schlievert PM. Purpura Fulminans due to Staphyloccus aureus. Clin Inf Dis. 2005; 40(7):941-7.

11. Ward KM, Celebi JT, Gmyrek R, Grossman ME. Acute infectious purpura fulminans associated with asplenism or hyposplenism. J Am Acad Dermatol. 2002; 47(4):493-496.

12. Cone LA, B Waterbor R. Sofonio MV. Purpura fulminans due to Streptococcus pneumoniae sepsis following gastric bypass. Obes Surg. 2004; 14(5):690-4.

13. Powars DR, Rogers ZR, Patch MJ, McGehee WG, Francis RB Jr. Purpura fulminans in meningococcemia: association with acquired deficiencies of proteins C and S. N Engl J Med. 1987;317(9):571-572.

14. Smith OP, White B, Vaughan D, Rafferty M, Claffey L, Lyons B, Casey W. Use of protein-C concentrate, heparin and haemodiafiltration in meningococcus-induced purpura fulminans. Lancet. 1997; 350(9091):1590-3.

15. Abraham E. Coagulation abnormalities in acute lung injury and sepsis. Am J Respir Cell Mol Biol. 2000; 22(4):401-4.

16. Ettingshausen CE, Veldmann A, Beeg T, Schneider W, Jager G, Kreuz W. Replacement therapy with protein C concentrate in infants and adolescents with meningococcal sepsis and purpura fulminans. Semin Thromb Hemost. 1999;25(6):537-41.

17. Bachli EB, Vavricka SR, Walter RB, Leschinger MI, Maggiorini M. Drotrecogin alfa (activated) for the treatment of meningococcal purpura fulminans. Intensive Care Med. 2003; 29(2):337.

18. Oelschlager C, Romisch J, Staubitz A, Stauss H, Leithauser B, Tillmanns H, Holschermann H. Antithrombin III inhibits nuclear factor kappaB activation in human monocytes and vascular endothelial cells. Blood. 2002; 99(11):4015-20.

19. Meyer MT, Irazuzta JE, Tozibikian H. Topical nitroglycerin and pain in purpura fulminans. J Pediatr. 1999;134(5):639-41.

20. Irazuzta J, McManus ML. Use of topically applied nitroglycerin in the treatment of purpura fulminans. J Pediatr. 1990;117(6): 993-5.

21. Besner GE, Klamar JE. Integra Artificial Skin as a useful adjunct in the treatment of purpura fulminans. J Burn Care Rehabil. 1998;19(4):324-9.

22. Davis MD, Dy KM, Nelson S. Presentation and outcome of purpura fulminans associated with peripheral gangrene in 12 patients at Mayo Clinic. J Am Acad Dermatol. 2007;57(6):944-56.

image description image description


A. Williamssays: April 21, 2014 at 12:32 pm

My first thought was Stevens-Johnson syndrome. Where was the primary infection? Lungs? Had she been on other antibiotics prior to the treatment with the fluoroquinolone?

Reply to this comment »
Kristine Hoffmansays: April 22, 2014 at 8:32 pm

The primary infection was the lungs. The patient was not on any antibiotics prior to her admission.

Reply to this comment »

Post new comment

  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.

More information about formatting options

Image CAPTCHA
Enter the characters shown in the image.