Is FDG-PET A Better Imaging Option For Diabetic Osteomyelitis?

Start Page: 18
Hope C. Markowitz, BA, Harley B. Kantor, BA, Randy Cohen, DPM, and Khurram H. Khan, DPM

1. Lipsky BA. A report from the international consensus on diagnosing and treating the infected diabetic foot. Diabetes Metab. Res. Rev 2004; 20 (Suppl. 1): S68-S77.
2. Kumar R, Basu S, Torigian D, et al. Role of modern imaging techniques for the diagnosis of infection in the era of 18 F- Fluorodeoxyglucose positron emission tomography. Clin Microb Rev 2008; 21(1):209-224.
3. Schinabeck MK, Johnson JL. Osteomyelitis in diabetic foot ulcers. Prompt diagnosis can avert amputation. Postgrad Med 2005; 118(1):11-15.
4. Schauwecker DS. Osteomyelitis: diagnosis with In-111-labeled leukocytes. Radiology 1989; 171(1):141-146.
5. Termaat MF, Rajimakers PGHM, Scholten HJ, et al. The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: A systematic review and meta analysis. JBJS Am 2005; 87(11):2464-2471.
6. Dinh MT, Abad CL, Safdar N. Diagnostic accuracy of physical examination and imaging tests for osteomyelitis underlying diabetic foot ulcers: meta analysis. Clin Infect Dis 2008; 47(4):519-527.
7. Jeffcoate WJ, Lipsky BA. Controversies in diagnosing and managing osteomyelitis of the foot in diabetes. Clin Infect Dis 2004; 39(Suppl 2):S115-122.
8. De Winter F, van de Wiele C, Vogelaers D, et al. Flourine-28 Fluorodeoxyglucose-positron emission tomography: a highly accurate imaging modality for the diagnosis of chronic musculoskeletal infections. JBJS 2001; 83-A(5):651-660.
9. Basu S, Chryssicos T, Houseni M, et al. Potential role of the FDG PET in the setting of diabetic neuro-osteoarthropathy: can it differentiate uncomplicated Charcot’s neuroarthropathy from osteomyelitis and soft tissue infection? Nucl Med Commun 2007; 28(6):465-472.
10. De Winter F, Vogelaers D, Gemmel F, et al. Promising role of 18-F-flouro-D-deoxyglucose positron emission tomography in clinical infectious diseases. Eur J Clin Microb Infect Dis 2002; 21(4):247-257.
11. Zhuang H, Sam JW, Chacko TK, et al. Rapid normalization of osseous FDG uptake following traumatic or surgical fractures. Eur J Nucl Med Mol Imaging 2003; 30(8):1096-1103.
12. Hartmann A, Eid K, Dora C, et al. Diagnostic value of (18)F-FDG PET/CT in trauma patients with suspected chronic osteomyelitis. Eur J Nucl Med Mol Imaging 2006; 34(5):704-714.
13. Zhuang H, Duarte PS, Pourdehand M, et al. Exclusion of chronic osteomyelitis with F-18 flourodeoxyglucose positron emission tomographic imaging. Clin Nucl Med 2000; 25(4):281-284.
14. Zhuang H, Cortes-Blanco A, Pourdehand M, et al. Do high glucose levels have differential effect on FDG uptake in inflammatory and malignant disorders? Nucl Med Commun 2001; 22(10):1123-1128.
15. Khan N, Oriuchi N, Higuchi T, et al. Review of FDG-PET: The FDG-PET imaging protocol. Cancer Control 2005; 12(4):254-260
16. Basu S, Chryssikos T, Moghadam-Kia S, et al. Positron emission tomography as a diagnostic tool in infection: Present role and future posibilities. Semin Nucl Med 2009; 39(1):36-51.
17. Keidar Z, Militianu D, Melamed E, Bar Shalom R, Israel O. The diabetic foot: Initial experience with 18F-FDG PET/CT. J Nucl Med 2005; 46(3):444-449.
18. Israel O, Keidar Z, Iosilevsky G, et al. The fusion of anatomic and physiologic imaging in the management of patients with cancer. Semin Nucl Med 2001; 31(3):191-205.
19. Nawaza A, Torigian DA, Siegelman ES, et al. Diagnostic performance of FDG-PET, MRI, and plain film radiography (PFR) for the diagnosis of osteomyelitis in the diabetic foot. Mol Imaging Biol 2009. Epub ahead of print.
Additional Reference
20. Lipsky BA. Osteomyelitis of the foot in diabetic patients. Clin Infect Dis 1997; 25(6):1318-1326.

image description image description

Post new comment

  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.

More information about formatting options

Enter the characters shown in the image.