Current Concepts In Diagnosing And Treating Drop Foot

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A Guide To Common Foot Drop Etiologies

• Hypothyroidism
• Lymphomas
(Hodgkin’s or non-Hodgkin’s)
• Guillain-Barré Syndrome
• HIV infection
• Cytomegalovirus infection
• Diabetes
• Megaloblastic anemia
• Intracranial tumors
• Brain lesions
• Tumors of the head and neck
• Trauma (direct injury)
• Antineoplastic drugs
• Spinal cord compression
• Direct peripheral
nerve invasion
• Autoimmunity
• Obesity or weight loss
• Idiopathic
• Local tumors such as ganglion or synovial cysts
• Nerve sheath tumors (schwannoma)
• Neurofibroma
• Bone tumors
• Postural (prolonged squatting, sitting or kneeling)
• Prolonged hospitalization
• Bed rest
• Internal surgery
(positioning on table)
• Ankle inversion/sprains
• Orthopedic (fibular fractures)
• Cast immobilization
• Tibial plateau repair/fracture
• Knee arthroplasty
• Hip surgery

Nicholas Romansky, DPM, Kelly Scollon-Grieve, MD, and James G. McGinness, CPO

   Drop foot can occur prior to lumbosacral spine surgical nerve decompression as a result of nerve decompression or because of an intraoperative complication of decompression. The etiology in these cases revolves around acute and chronic lumbar degeneration.4 Typically, the result of surgical nerve decompression depends on the acute or chronic nature as well as magnitude and duration of compression of the L-S spine. If surgery occurs, most improvement occurs six weeks postoperatively.

   Drop foot can occur following hip and knee replacement with damage and localized hematoma to the sciatic nerve and its branches. This is especially the case if bleeding occurs at the operative site.

   For a full list of drop foot etiologies, see “A Guide To Common Drop Foot Etiologies” at right).4-9

Pertinent Pearls On The Workup And Diagnosis Of Drop Foot

The workup of a drop foot should include a thorough neurologic exam to rule out any more serious central or primary causes of the drop foot. This includes motor strength testing and sensation and reflex examination of all limbs, including assessment for pathologic reflexes such as Babinski, Hoffmann’s and clonus reflexes.

   Physicians must access the entire clinical picture through the use of laboratory studies and other diagnostic modalities. Nerve conduction and electromyographic studies are an important extension of the neurologic examination as they can help zero in on the local site of injury, establish the degree of damage and predict the degree of recovery. Laboratory studies to evaluate for a metabolic or toxic cause may be indicated if there is no trauma or obvious cause for the drop foot. The following tests are useful: fasting blood sugar, hemoglobin A1c, erythrocyte sedimentation rate, C-reactive protein, serum protein electrophoresis, blood urea nitrogen, creatinine and vitamin B12 levels.1

   Imaging is also important in establishing the cause of drop foot. If there is trauma to the area, plain films of the tibia and fibula are indicated to determine if there is any bony injury. One may employ magnetic resonance imaging (MRI) to help evaluate for local tibia/fibula injury, brain injury, spinal cord pathology or nerve root impingement. Ultrasound evaluation of the peroneal nerve may be useful in assessing for a focal entrapment around the fibular head.1

   One must take numerous factors into account when deciding on the treatment approach for the individual with drop foot. The etiology, chronicity, prognosis, distribution, location, severity and medical comorbidities are critical factors. Treatment modalities can consist of nonsurgical, surgical and brace assistance, or any combination of the above.

How Effective Are AFOs And Bracing?

Bracing with an AFO and physical therapy is useful in all causes of drop foot to assist in ambulation and prevent contracture of the ankle plantar flexors. Clinicians may use conventional AFOs for those who would benefit from minimal skin contact. These patients would include those who have lower limb swelling, circulation concerns, and/or insensitivity.

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