Combating The Impact Of Oxygen Free Radicals On DFU Healing

Author(s): 
Jeffrey A. Niezgoda, MD, FACHM, FAPWCA, Kimberly Eldridge, RN, CWS, Richard Millis, PhD, Milton Kondiles, DPM, and Rebecca D. Snarski, PhD

   One of these therapies is Wound-Be-Gone (Wake Pharma), which includes FDA approved ingredients that bind with oxygen free radicals and neutralize them while simultaneously facilitating a moist healing environment to help speed healing time. Authors have demonstrated clinically that this therapy stabilizes the inflammation associated with diabetic foot ulcers and other wounds, and contributes to improved wound healing.7 While this novel therapeutic option has promise, additional research regarding this technology is warranted.

Final Notes

Given the need to facilitate more rapid closure of diabetic foot wounds, the continued development of adjunctive modalities to help address the problematic impact of oxygen free radicals is key. Further research in this area is encouraged and may ultimately aid physicians and clinicians in thwarting complications such as hypoxia and ischemia, and facilitating improved outcomes in a high-risk population.

   Dr. Niezgoda is the Medical Director of the Centers for Comprehensive Wound Care and Hyperbaric Oxygen Therapy at Aurora Health Care in Milwaukee. He is the President and Chief Operating Officer of Hyperbaric and Wound Care Associates in Milwaukee.

   Dr. Eldridge practices at Rush Hospital Wound Care, Hyperbaric and Limb Salvage Center in Meridian, Miss.

   Dr. Mills is an Associate Professor in the Department of Physiology and Biophysics at the Howard University College of Medicine in Washington, D.C.

   Dr. Kondiles practices at Chicagoland Foot Care at the Center for Wellness and Neuropathy in Chicago. He is a Fellow of the American College of Foot and Ankle Surgeons.

   Dr. Snarski is a professor at Capella University in Minneapolis and teaches research skills to graduate level technology students.

   Dr. Steinberg is an Assistant Professor in the Department of Plastic Surgery at the Georgetown University School of Medicine in Washington, D.C. Dr. Steinberg is a Fellow of the American College of Foot and Ankle Surgeons.

   Editor’s note: For related articles, see “Key Insights On Using Hyperbaric Oxygen For Wounds” in the January 2010 issue of Podiatry Today or “Is There A Role For HBOT In Limb Salvage?” in the August 2008 issue.




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