Can Botulinum Toxin Have An Effect For Hyperhidrosis?

Suzanne M. Levine, RPT, DPM, and Everett M. Lautin, MD, FACR

1. Strutton DR, Kowalski JW, Glaser DA, Stang PE. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004; 51(2):241-248.
2. Loureiro M de P, de Campos JRM, Kauffman P, Jatene FB, Weigmann S, Fontana A. Endoscopic lumbar sympathectomy for women: effect on compensatory sweat. Clinics (Sao Paulo). 2008; 63(2):189-196.
3. Erbguth FJ. Historical notes on botulism, Clostridium botulinum, botulinum toxin, and the idea of the therapeutic use of the toxin. Mov Disord. 2004; 19(Suppl 8):S2-6.
4. Dhaked RK, Singh MK, Singh P, Gupta P. Botulinum toxin: bioweapon & magic drug. Indian J Med Res. 2010; 132(5):489-503.
5. Sobel J. Botulism. Clin Infect Dis. 2005; 41(8):1167-1173.
6. Smith LA. Botulism and vaccines for its prevention. Vaccine. 2009; 27(Suppl 4):D33-39.
7. Cherington M. Clinical spectrum of botulism. Muscle Nerve. 1998; 21(6):701-710.
8. Hambleton P. Clostridium botulinum toxins: a general review of involvement in disease, structure, mode of action and preparation for clinical use. J Neurol. 1992; 239(1):16-20.
9. Torrens JK. Clostridium botulinum was named because of association with “sausage poisoning.” BMJ. 1998; 316(7125):151-151.
10. Ting PT, Freiman A. The story of Clostridium botulinum: from food poisoning to Botox. Clin Med. 2004; 4(3):258-261.
11. Dolly JO, Aoki KR. The structure and mode of action of different botulinum toxins. Eur J Neurol. 2006; 13(Suppl 4):1-9.
12. O’Flaherty SJ, Janakan V, Morrow AM, Scheinberg AM, Waugh M-CA. Adverse events and health status following botulinum toxin type A injections in children with cerebral palsy. Dev Med Child Neurol. 2011; 53(2):125-130.
13. Medication Guide Botox® Cosmetic(onabotulinum toxin A) for Injection. 2010; Available from:
14. Li M, Goldberger BA, Hopkins C. Fatal case of BOTOX-related anaphylaxis? J Forensic Sci. 2005; 50(1):169-172.
15. Available at
16. Naumann M, Carruthers A, Carruthers J, Aurora SK, Zafonte R, Abu-Shakra S, Boodhoo T, Miller-Messana MA, Demos G, James L, Beddingfield F, VanDenburgh A, Chapman MA, Brin MF. Meta-analysis of neutralizing antibody conversion with onabotulinumtoxinA (BOTOX®) across multiple indications. Mov Disord. 2010; 25(13):2211-2218.
17. Kuehn BM. FDA requires black box warnings on labeling for botulinum toxin products. JAMA. 2009; 301(22):2316.
18. Narayanan UG. Botulinum toxin: does the black box warning justify change in practice? Dev Med Child Neurol. 2011; 53(2):101-102.
19. Botox Product Information: BOTOX® Cosmetic(onabotulinumtoxinA)for injection [Internet]. Available from:
20. Wohlfarth K, Kampe K, Bigalke H. Pharmacokinetic properties of different formulations of botulinum neurotoxin type A. Mov Disord. 2004; 19(Suppl 8):S65-67.
21. Simonetta Moreau M, Cauhepe C, Magues JP, Senard JM. A double-blind, randomized, comparative study of Dysport vs. Botox in primary palmar hyperhidrosis. Br J Dermatol. 2003; 149(5):1041-1045.
22. Güleç A. Dilution of botulinum toxin A in lidocaine vs. in normal saline for the treatment of primary axillary hyperhidrosis: a double-blind, randomized, comparative preliminary study. J Eur Acad Dermatol Venereol. 2011; Epub ahead of print.
23. Shome D, Nair AG, Kapoor R, Jain V. Botulinum toxin A: is it really that fragile a molecule? Dermatol Surg. 2010 ;36(Suppl 4):2106-2110.
24. Gregoriou S, Rigopoulos D, Makris M, Liakou A, Agiosofitou E, Stefanaki C, Kontochristopoulos G. Effects of botulinum toxin-a therapy for palmar hyperhidrosis in plantar sweat production. Dermatol Surg. 2010; 36(4):496-498.

Add new comment