Off-Label Drug Promotion: Coming Soon?

Warren S. Joseph DPM FIDSA
12/18/12 | 2469 reads | 0 comments
The U.S. Second Circuit Court of Appeals recently ruled to prohibit criminal prosecution for truthful off-label promotion of drugs as a First Amendment right. An excellent analysis of the case by the law firm of Morgan, Lewis and Bockius is available at: http://tinyurl.com/bv5xase . I direct anyone interested to read this summary. I will not go into details but rather discuss how this may affect antibiotics and lower extremity infections. Read More.

What The Recent Literature Reveals About Antibiotic Use And Multi-Drug Resistant Gram Negative Rods

Warren S. Joseph DPM FIDSA
8/22/12 | 2546 reads | 0 comments
I confess that I have been a bit lackadaisical in my scanning through the journals I receive each month. This point hit home the other day when I went to find room on my desk to put some work and realized it was totally covered with stacks of journal back issues I had put aside with all good intentions to eventually read through. It was time to start clearing my desk with the side benefit of realizing I could probably come up with some interesting articles to blog about. Well, I did. In fact, I think I have enough for a few upcoming posts. Read More.

Reaching Out To The Public To Save A Leg, Save A Life

Warren S. Joseph DPM FIDSA
7/20/12 | 2297 reads | 0 comments
On July 15, I had the pleasure of participating in a radio interview on WOKV in Jacksonville, Fla., the largest talk radio station in northern Florida. Here is the link to the audiostream: http://wokv.media.streamtheworld.com/audio/save_leg_save_101730761.mp3 . Read More.

Evaluating Diabetic Foot Infections With The New IDSA Guidelines

Warren S. Joseph DPM FIDSA
5/29/12 | 5161 reads | 0 comments
I promised I would post a link to the newly revised, updated Infectious Diseases Society of America (IDSA) Diabetic Foot Infection Guidelines as soon as they were available. Read More.

What You Should Know About Antibiotic Bone Penetration And Osteomyelitis

Warren S. Joseph DPM FIDSA
4/9/12 | 6592 reads | 0 comments
Steven Klein, DPM, a reader of this blog, emailed me to ask the following questions. I have obtained his permission to use his excellent thoughts as a “jumping off” point for this post and some subsequent ones to follow. Read More.

Emerging Trends In Antibiotic Prescriptions By Podiatrists

Warren S. Joseph DPM FIDSA
1/30/12 | 6304 reads | 8 comments
I recently came across some fascinating data that breaks down the number of outpatient prescriptions written by podiatrists for all different classes of drugs in 2010. Unlike various surveys that have been done over the years by different magazines, this is hard data based on the actual number of scripts. I would like to comment on some findings I find interesting in the use of antibiotics. Read More.

A New Review Of Antibiotic Therapy For Osteomyelitis

Warren S. Joseph DPM FIDSA
1/10/12 | 4725 reads | 0 comments
I wish all of my readers a healthy, happy and prosperous 2012. With this post, I am trying something a bit different. In the past, I usually waited to put up a post until I come up with an “aha” moment on something I have seen, heard or read about, and then pontificate on this site. These moments could occur only days apart but usually it was a much longer time period leading to relatively infrequent additions to the blog. Read More.

Are Surgical Prophylaxis Requirements At Hospitals Effective Or Do They Inadvertently Encourage Superfluous Antibiotic Use?

Warren S. Joseph DPM FIDSA
11/23/11 | 3820 reads | 0 comments
One of the most frequent questions people ask me is about when to use antibiotic prophylaxis in performing foot and ankle surgery. I have an entire lecture on this topic. In this lecture, I go through the data, or lack thereof, on the subject and enumerate the clinical situations (i.e. surgery longer than two hours, trauma surgery, immunocompromised hosts, etc.) in which surgeons have traditionally utilized prophylaxis. Read More.

What You Should Know About Linezolid And Psychiatric Medications

Warren S. Joseph DPM FIDSA
10/31/11 | 3679 reads | 0 comments
One of the trickiest issues in prescribing linezolid (Zyvox, Pfizer) for patients with methicillin resistant Staphylococcus aureus (MRSA) or vancomycin resistant Enterococcus (VRE) infections is the potential for a drug-drug interaction with various serotonergic psychiatric medications, leading to serotonin syndrome. It seems that every pharmacy computer system in the world goes crazy with warnings when you attempt to write for this antibiotic while the patient is on these meds. Read More.