Can Bisphosphonates Lead To Better Charcot Treatment?

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Here is a lateral radiograph of a midfoot Charcot deformity with recurrence after an attempted surgical reconstruction.
Here is a lateral radiograph that reveals complete rearfoot collapse due to Charcot.
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Author(s): 
By William Scott Rogers

1. Frykberg RG, Sanders LJ: Charcot Neuroarthropathy of the Foot. In Bowker JH, Pfeifer MA(ed): Levin and O’Neals The Diabetic Foot- 6th ed. St. Louis: Mosby, 2001, pp 439-462.

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3. Gough A, Abraha H, Li F, et al: Measurement of markers of osteoclast and osteoblast activity in patients with acute and chronic diabetic Charcot neuroarthropathy. Diabet Med 14:527-531, 1997.

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6. Package insert. West Point, PA: Merck and Co, Inc., August 1999.

7. Package insert. East Hanover, NJ: Novartis Pharmaceuticals Corporation, July 1999.

8. Selby PL, Young MJ, Boulton AJM: Bisphosphonates: A new treatment for diabetic Charcot neuroarthropathy? Diabet Med 11:28-31, 1994.

9. Guis S, Pellissier JE, Arniaud D, Turck F, Witjas, Roux H, Mattei JP. Healing of Charcot’s joint by pamidronate infusion. J Rheumatol 26(8):1843-50, 1999.

10.Young MJ: The management of neurogenic arthropathy: A tale of two charcots. Diabetes Metab Res Rev 15(1):59-64, 1999.

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