Dedicating oneself to the side of limb salvage in the fight against diabetic foot disease is a demanding and personally challenging enterprise. In the face of infection, it often seems as though all variables are against the surgeon and the patient as they both struggle against the possibilities of proximal amputation and limb loss. In fact, it often appears as though the only constant is the unpredictability of the disease progression. However, expert knowledge in lower extremity anatomy is one of the most valuable tools that one can have in this fight. This knowledge allows one to answer the following key questions: • Where is the infection coming from? • Where is the infection going? • Where will the healing come from? Answering these three questions in the preoperative patient evaluation will assist in completing a planned, appropriate debridement as opposed to an aggressive but destructive procedure with little hope of viable outcome.