A Closer Look At The Research Behind MIRE Therapy

Author(s): 
By Lawrence Lavery, DPM, MPH

   The quality of the clinical data is suspect and the ability of therapy to “reverse neuropathy” and prevent foot complications (such as ulceration, infection and amputation) related to sensory neuropathy is unproven. Further research needs to address design and analysis concerns.

Dr. Lavery (shown at the right) is a Professor in the Department of Surgery at Texas A&M Health Science Center College of Medicine.

Dr. Steinberg (shown at the left) is an Assistant Professor in the Department of Plastic Surgery at the Georgetown University School of Medicine in Washington, D.C.

Editor’s note: For further reading, see “Current And Emerging Options For Treating Diabetic Neuropathy” in the March 2005 issue of Podiatry Today.




References:

References
1.    Harkless LB, Delellis, Carnegie DH, Burke TJ. Improved foot sensitivity and pain reduction in patients with peripheral neuropathy after treatment with monochromatic infrared photo energy. J Diabetes Compl 20(2006) 81-87.
2.    Powell MW, Carnegie DE, Burke TJ. Reversal of diabetic neuropathy and new wound incidence: the role of MIRE. Adv Skin Wound Care 17:295-300, 2004.
3.     Powell MW, Carnegie DE, Burke TJ. Reversal of diabetic neuropathy and new wound incidence: the role of MIRE. Adv Skin Wound Care 17:295-300, 2004.
4.     DeLellis SL, Carnegie DH Burke TJ. Improvement of sensitivity in patients with peripheral sensory neuropathy. J Am Podiatr Med Assoc 95: 143-147, 2005.
5.     Prendergrast JJ, Miranda G, Sanchez M. Improvement sensory impairment in patients with peripheral sensory neuropathy. Endocr Prac 10: 24-30, 2004.
6.     Kochman AB, Carnegie DH, Burke TJ. Symptomatic reversal of peripheral neuropathy in patients with diabetes. J Am Podiatr Med Assoc, 2002. 92(3):125-30.
7.     Leonard DR, Farooqi MH, Myers S. Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy: a double-blind, randomized, placebo-controlled study with monochromatic near-infrared treatment. Diabetes Care, 2004. 27(1):168-72.
8.     Arnall DA, et al. The restorative effects of pulsed infrared light therapy on significant loss of peripheral protective sensation in patients with long-term type 1 and type 2 diabetes mellitus. Acta Diabetol, 2006. 43(1):26-33.
9.     Clifft JK, et al. The effect of monochromatic infrared energy on sensation in patients with diabetic peripheral neuropathy: a double-blind, placebo-controlled study. Diabetes Care, 2005. 28(12):2896-900.
10.    Yong R, et al. The durability of the Semmes-Weinstein 5.07 monofilament. J Foot Ankle Surg, 2000. 39(1):34-8.
11.     McGill M, et al. Possible sources of discrepancies in the use of the Semmes-Weinstein monofilament. Impact on prevalence of insensate foot and workload requirements. Diabetes Care, 1999. 22(4):598-602.
12.     Booth J, Young MJ. Differences in the performance of commercially available 10-g monofilaments. Diabetes Care, 2000. 23(7):984-8.

Additional References
13.     Armstrong DG, Lavery LA, Quebedeaux TL, Fleishli JG, Vela S: Choosing a Practical Screening Instrument to Identify Patients at Risk for Diabetic Foot Ulceration. Arch Int Med 158: 289-292, 1998.
14.     Diamond JE, et al. Reliability of a diabetic foot evaluation. Phys Ther, 1989. 69(10):797-802.
15.     Mueller MJ, et al. Insensitivity, limited joint mobility, and plantar ulcers in patients with diabetes mellitus. Phys Ther, 1989. 69(6):453-9; discussion 459-62.

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