Can Incretin Mimetics Improve Beta Cell Dysfunction

Volume 20 - Issue 2 - February 2007
5447 reads
0 comments

Start Page: 19

When it comes to patients with uncontrolled diabetes, the authors say exenatide injection improves blood sugars, beta cell function and beta cell mass.

Patients would inject Byetta twice a day before meals, delivering doses of 5 mcg or 10 mcg. It is contraindicated in patients with type 1 diabetes and in those undergoing diabetic ketoacidosis treatment.

Can Incretin Mimetics Improve Beta Cell Dysfunction

Author(s):

By Mackenzi Nelson, DPM, and John S. Steinberg, DPM

1. Kahn, C. Ronald, Weir GC, King GL, Jacobson AM, Moses AC, Smith RJ: “History of Diabetes.” Joslin’s Diabetes Mellitus, 14th Edition. 2005 ed.
2. Kendall DM, Kim D, Maggs D: Incretin mimetics and dipeptidyl peptidase-IV inhibitors: a review of emerging therapies for type 2 diabetes. Diabetes Technol Ther 2006; 8(3):385-396.
3. Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG: Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial. Annals of Internal Medicine 2005; 143(8):559-569.
4. Mikhail NE: Is exenatide a useful addition to diabetes therapy? Endocr Pract 2006; 12(3):307-314.
5. Salehi M, D’Alessio DA: New therapies for type 2 diabetes based on glucagons-like peptide 1. Cleveland Clinic Journal of Medicine 2006; 73:382-389.
6. Kendall DM, Riddle MC, Rosenstock J, Zhuang D, Kim DD, Fineman MS, Baron AD: Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005; 28(5):1083-1091.
7. Young AA, Bronislava RG, Bhavsar S, Bodkin N, Jodka C, Hansen B, Denaro M: Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 1999; 48:1026-1034.
8. Amylin Pharmaceuticals, Inc. http://www.BYETTA.com
9. Gila Monster Fact Sheet – National Zoo. http://nationalzoo.si.edu/animals/reptilesamphibians/facts/factsheets/gi...
10. Christel CM, DeNardo DF: Release of exendin-4 is controlled by mechanical action in Gila Monsters, Heloderma suspectum. Comparative Biochemistry and Physiology 2006; Part A 143:85-88.
11. Young A, Blasé E, Petrella E, Seward M: Exendin-4 is a circulating meal-related peptide in the Gila monster (Heloderma suspectum). Diabetes 1999a; 48:A425.
12. Diabetes Monitor. http://www.diabetesmonitor.com/byetta.htm.