Choose the single best answer to the following questions.
1. Which medications were evaluated in the SIDESTEP study, the largest study to date of diabetic foot infections?
a) linezolid and daptomycin
b) ertapenem and linezolid
c) ertapenem and piperacillin/tazobactam
d) pexiganan and ertapenem
2. At the discontinuation of intravenous antibiotic therapy in the SIDESTEP study, the favorable clinical response rate in those treated with ertapenem was_____.
a) 52 percent
b) 81 percent
c) 75 percent
d) 94 percent
3. The SIDESTEP study primarily enrolled patients with ...
a) mild diabetic foot infections
b) methicillin-resistant Staph aureus infections
c) moderate to severe diabetic foot infections
d) diabetic foot osteomyelitis
4. What are the two most common organisms isolated in diabetic foot infections?
a) Enterococcus and Pseudomonas
b) Staph aureus and group B-Streptococcus
c) Pseudomonas and MRSA
d) Enterococcus and group B-Streptococcus
5. In regard to ertapenem’s spectrum of activity, which of the following statements is true?
a) It is an effective agent against gram-positive anaerobic organisms, like Peptostreptococcus.
b) It is an effective agent against gram-positive anaerobes, like staphylococci (methicillin-sensitive) and streptococci.
c) In comparison to piperacillin/tazobactam, ertapenem is less effective against Pseudomonas aeruginosa and enterococci.
d) All of the above
6. What were the two basic components of the wound scoring system that was utilized in the SIDESTEP study?
a) wound size and patient age
b) degree of inflammation and wound size
c) causative organisms and degree of inflammation
d) None of the above
7) The cited 1990 study by Lipsky, Pecoraro, et. al., emphasized ______ as primary pathogens in diabetic foot infections.
a) obligate anaerobic organisms
b) aerobic gram-positive organisms
c) aerobic gram-negative organisms
d) None of the above
8) Data from the SIDESTEP study and others suggest that ...
a) Pseudomonas and enterococci are almost never isolated from diabetic foot infections.
b) Pseudomonas and enterococci are sometimes isolated but usually in mixed infections.
c) Pseudomonas and enterococci do not necessarily need to be specifically targeted in antibiotic selection.
d) Anaerobic organisms are not important in diabetic foot infections.
e) b and c
9. Which of the following patients were excluded from the SIDESTEP study?
a) Patients with moderate diabetic foot infections
b) All patients with osteomyelitis in whom all infection was resected.
c) Patients with critical limb ischemia that required revascularization.
d) All of the above.
10. Ertapenem is specifically FDA indicated for ...
a) moderate to severe diabetic foot infections without osteomyelitis
b) MRSA
c) moderate to severe complicated skin/skin structure infections
d) a and c |
