Can A New Biologic Matrix Facilitate Improved Wound Healing?

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Here is a view of a wound that resulted from a partial calcanectomy. Note the meshed Integra secured with staples.
Can A New Biologic Matrix Facilitate Improved Wound Healing?
Here is a view of the same wound two weeks after application of Integra, a non-adherent wound cover, a silver impregnated sheet and a negative pressure dressing. Note that the silicone layer has been removed from the wound surface while leaving the matrix
By Ann Anderson, DPM, and John S. Steinberg, DPM

1. Molnar JA, DeFranzo AJ, Hadaegh A, Morykwas MJ, Shen P, Argenta LC. Acceleration of Integra Incorporation in Complex Tissue Defects with Subatmospheric Pressure. Plastic and Reconstructive Surgery 113(5); 1339 – 1346, 2004.
2. Ryan CM, Schoenfeld, DA, Malloy M, Schulz III JT, Sheridan RL, Tompkins RG. Use of Integra artificial skin is associated with decreased length of stay for severely injured adult burn survivors. J Burn Care Rehabil. 2002 Sep-Oct;23(5):311-7.
3. Yannas IV and Burke JF. Design of an artificial skin. Basic design principles. J Biomedical Materials Research 14; 65-81, 1980.
4. Yannas IV. Studies on the biological activity of the dermal regeneration template. Wound Repair and Regeneration 6 (6); 518-523, 1998.
5. Heimbach D, Luterman A, Burke J, Cram A, Herndon D, Hunt J, Jordan M, McManus W, Solem L, Warden G, Zawacki B. Artificial Dermis for Major Burns. Annals of Surgery 208(3); 313 – 320, 1988.

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