Assessing The Potential Wound Healing Abilities Of Ciclopirox

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Assessing The Potential Wound Healing Abilities Of Ciclopirox
Here one can see severe vesicular tinea pedis. When this type of fungal infection — with major involvement and blisters — is present among patients with diabetes, it can develop into a chronic ulcer.
Here is an ulcer with tinea pedis. This ulcer developed from a previously fungally infected area in a patient with diabetes.
Assessing The Potential Wound Healing Abilities Of Ciclopirox
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Author(s): 
By Gary L. Dockery, DPM, FACFAS

1. Aly R, Maibach HI, Bagatell FK, Dittmar W, Hänel H, Falanga V, et al: Ciclopirox olamine lotion 1%: bioequivalence to ciclopirox olamine cream 1% and clinical efficacy in tinea pedis. Clin Ther. 1989;11(3):290-303.
2. Jue SG, Dawson GW, Brogden RN: Ciclopirox olamine 1% cream: a preliminary review of its antimicrobial activity and therapeutic use. Drugs. 1985;29:330-341.
3. Rosen T, Schell BJ, Orengo I: Anti-inflammatory activity of antifungal prepatations. Int J Dermatol. 1997;36(10):788-792.
4. Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH: The antimycotic ciclopirox olamine induces HIF-1a stability, VEGF expression, and angiogenesis. FASEB J [serial online] February 19, 2003. Available at: http://www.fasebj.org/cgi/doi/10.1096/fj.02-0586fje. Accessed April 30, 2004.
5. Dockery GL: Can ciclopirox shampoo help combat fungal infections of the feet? Podiatry Today. June 2004:20-26.
6. Höckel M, Schlenger K, Doctrow S, Kissel T, Vaupel P: Therapeutic angiogenesis. Arch Surg. 1993;128:423-429. Cited by: Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH: The antimycotic ciclopirox olamine induces HIF-1a stability, VEGF expression, and angiogenesis. FASEB J [serial online] February 19, 2003. Available at: http://www.fasebj.org/cgi/doi/10.1096/fj.02-0586fje. Accessed April 30, 2004.
7. Morishita R, Aoki M, Kaneda Y, Ogihara T: Gene therapy in vascular medicine: recent advances and future perspectives. Pharmacol Ther. 2001;91:105-114. Cited by: Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH: The antimycotic ciclopirox olamine induces HIF-1a stability, VEGF expression, and angiogenesis. FASEB J [serial online] February 19, 2003. Available at: http://www.fasebj.org/cgi/doi/10.1096/fj.02-0586fje. Accessed April 30, 2004.
8. Isner JM: Myocardial gene therapy. Nature. 2002;415:234-239. Cited by: Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH: The antimycotic ciclopirox olamine induces HIF-1a stability, VEGF expression, and angiogenesis. FASEB J [serial online] February 19, 2003. Available at: http://www.fasebj.org/cgi/doi/10.1096/fj.02-0586fje. Accessed April 30, 2004.
9. Jones MK, Kawanaka H, Baatar D, Szabo IL, Tsugawa K, Pai R, et al: Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1. Gastroenterol. 2001;121:1040-1047. Cited by: Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH: The antimycotic ciclopirox olamine induces HIF-1a stability, VEGF expression, and angiogenesis. FASEB J [serial online] February 19, 2003. Available at: http://www.fasebj.org/cgi/doi/10.1096/fj.02-0586fje. Accessed April 30, 2004.
10. Szabo S, Deng X, Khomenko T, Yoshida M, Jadus MR, Sandor Z, et al: Gene expression and gene therapy in experimental duodenal ulceration. J Physiol (Paris). 2001;95:325-335. Cited by: Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH: The antimycotic ciclopirox olamine induces HIF-1a stability, VEGF expression, and angiogenesis. FASEB J [serial online] February 19, 2003. Available at: http://www.fasebj.org/cgi/doi/10.1096/fj.02-0586fje. Accessed April 30, 2004.
11. Corral CJ, Siddiqui A, Wu L, Farrell CL, Lyons D, Mustoe TA: Vascular endothelial growth factor is more important than basic fibroblastic growth factor during ischemic wound healing. Arch Surg. 1999;134:200-205. Cited by: Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH: The antimycotic ciclopirox olamine induces HIF-1a stability, VEGF expression, and angiogenesis. FASEB J [serial online] February 19, 2003.

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