Current Options In Treating Chronic Venous Ulcers

By Michael Baker, DPM, CWS

As foot and ankle surgeons, we are constantly reminded that we are the ultimate champions of diabetic foot care. However, another emerging problem is chronic venous insufficiency (CVI) ulcerations. While it does not have nearly the potential impact of limb loss one may see with complications from the diabetic foot, there is an increasing incidence of CVI with the continued aging of the population. According to current estimates, CVI affects between 0.1 and 0.3 percent of the total population in the United States. The healthcare industry spends $400 million annually on treating CVI. Unlike the diabetic foot, there is minimal limb mortality with CVI, but very high pain morbidity. In regard to the development of venous hypertension, pressure on the venous side starts to equalize with the arterial side, obstructing normal blood flow. This pooling of blood can lead to valvular incompetence, allowing blood to be pushed from deep to superficial directions and from superior to inferior directions. A Closer Look At Venous Inflammation When it comes to the development of venous inflammation, other hemodynamic events occur when blood slows or reverses from the lower extremity. The calf musculator, which acts as a venous pump, forces a backward blood flow as a hydraulic ram. This reverse pressure pushes molecules and cells into areas where they do not belong. Large monocytes are forced into small venules and large protein molecules (fibrinogen) are subsequently forced out of the vessel wall. There are two leading theories of what causes inflammation with CVI. “White cell trapping theory” contends that capillaries are present where they do not fit. This stretches the endothelial wall of the vessel, exposing collagen to the monocyte which allows binding and activation to macrophage. The activation macrophage starts the cellular inflammatory response in the blood vessel. The second theory posits that macromolecules such as fibrinogen are forced from the capillary due to venous hypertension. These large molecules become plentiful around the capillary, causing a “fibrin cuff.” This cuff acts as a barrier to the exchange of oxygen and essential nutrients. Key Diagnostic Insights If CVI is allowed to continue, inflammation will develop, resulting in the appearance of physical signs. First, the edema can lead to an inverted bowling pin appearance of the leg. One may also see skin changes of hyperpigmentation, lipodermatosclerosis and induration in the perimalleolar and supramalleolar regions. If these signs are ignored, minor trauma may result in a long-term, painfully debilitating ulceration. As far as the diagnostic workup goes, always start with a thorough history and physical exam as few wounds will heal if existing comorbidities are not controlled and the etiology of the wound is not identified and treated. When it comes to diagnosing venous stasis ulcerations, one should consider the use of duplex ultrasonography, ankle-brachial index (ABI), venography and culture and sensitivity as well as a biopsy. Duplex ultrasonography has good sensitivity and specificity for valvular incompetence. The ABI should be a part of any wound care workup when arterial flow is in question. Venography is more expensive and more dangerous. One should only reserve this modality for procedures in which a vascular surgeon is involved. Culture and sensitivity are effective for directing specific antibiotic usage. Obtaining a tissue biopsy is also essential with a CVI workup as many wounds mimic venous ulcerations. Reviewing The Various Treatment Options After obtaining wound measurements and photographs, and the results of tissue cultures and tissue biopsy, one can start to formulate a treatment plan. First, one has to ensure control of any comorbidities. One can reduce edema with elevation, compression wraps and/or stockings, compression pumps or physical therapy edema reduction programs. When it comes to perforating ulcers, one should seek a vascular consult for possible lentin or SEPS procedures. Vein sucrosing therapy is becoming popular for venous wounds but I have found limited results with this modality in my experience. One would subsequently address the wound itself. You may control bacterial counts with appropriate topical, oral and/or IV antibiotics. However, pain often becomes a barrier to weekly debridement or compression, both of which are necessary to achieve secondary healing. To overcome the pain barrier, one should consider alternative coverage techniques. There are many ways to cover a clean venous stasis ulceration and all of these alternatives can reduce pain. These options include Apligraf (Organogenesis), Dermagraft (Smith & Nephew) and cadaveric homografts. Cadaveric homografts should not be confused with skin grafts. Cadaveric homografts offer a very cost-effective biologic dressing that adheres and allow epithelialization to take place but keep in mind that they do not “take.” Apligraf and Dermagraft are commercially available dressings that deliver biologic products to the wound. Apligraf delivers collagen, growth factors, keratinocytes and fibroblasts to the wound. Dermagraft is adequate for delivering growth factors but does not deliver collagen. More recently, I have been covering the clean venous stasis wound with GraftJacket (Wright Medical), a unique allograft product that is freeze-dried instead of frozen. This prevents the collagen from being denaturalized. The GraftJacket is also taken specifically from cadaveric banks in order to improve graft quality. Preparation for application is dependent on the product. Instead of rehydrating the GraftJacket in saline or sterile water, our team has been hydrating it with the patient’s own platelet rich plasma (PRP). One can achieve this via gravitational blood separation systems such as Biomet’s Gravational Platelet Separation (GPS) or Harvest Technologies’ SmartPReP system. In my opinion, the GraftJacket should be meshed on a 1:1.5 mesh after rehydration. Theoretically, the platelets should be absorbed into the graft and subsequently facilitate a concentrated release of the patient’s own growth factors due to collagen exposure. Since the product is acellular, there is a reduced risk for rejection. In Conclusion In conclusion, I find that venous stasis ulcerations heal best with some type of graft coverage. Many commercial products are emerging to fill this purpose. My favorite on properly diagnosed, well prepared venous stasis ulcerations is the GraftJacket. Although all these products seem to reduce patient discomfort and speed epithelialization, the GraftJacket recipe seems to be the most consistent at this time. Dr. Baker is board-certified in foot and ankle surgery. He practices at the West View Wound Care Center in Indianapolis, Ind. Dr. Burks is a Fellow of the American College of Foot and Ankle Surgeons and is board-certified in foot and ankle surgery. Dr. Burks practices in Little Rock, Ark.

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