Exploring Alternative Treatment For Resistant Warts

Start Page: 56
This otherwise healthy patient inappropriately applied OTC 40% salicylic acid to his warts and presented with substantial pain caused by ulceration of the skin that was well beyond the viral tissue margins.
Here one can see a wart before treatment with 5-fluorouracil.
Here you can see the characteristic superficial ulceration that usually occurs between the fourth and tenth week of treatment with 5-fluorouracil. This ulceration is desirable as it indicates destruction of the lesion.
Here one can see the interruption of skin lines along with acanthosis, hyperkeratosis and small dark pinpoint dots representing thrombosed capillaries.
65
Author(s): 
By Robert Salk, DPM, Kirk Grogan, DPM, Thomas Chang, DPM, and Walter D’Costa, DPM

1. Bunney, MH, Nolan, MW, Williams, DA. An assessment of methods of treating viral warts by comparative treatment trials based on a standard design. Br J Dermatol 94:667-679, 1976.

2. Diasio R, Harris B. Clinical Pharmacology of 5-fluorouracil. Clinical Pharmacokinetics 1989:16:215-237.

3. Dahl M. Imiquimod: An Immune Response Modifier. J Am Acad Dermatology. July 2000:S1-S5.

4. Templeton S, et al. Intradermal Bleomycin Injections Into Normal Human Skin. Arch Derm. 1994:130:577-583.

5. Amer M, et al. Therapeutic Evaluation for Intralesional Injection of Bleomycin Sulfate in 143 Resistant Warts. J Am Acad Derm. 1988;18:1313-1316.

6. Shelly W, et al. Intralesional Bleomycin Sulfate Therapy for Warts. Arch Derm. 1991;127:234-236.

7. Johnson S, et al. Intralesional Injection of Mumps or Candida Skin Test Antigens. Arch Derm. 2001;137:451-455.

8. Focht DR, et al. The Efficacy of Duct Tape vs Cryotherapy in the Treatment of Verruca Vulgaris (The Common Wart). Arch Pedi Adolesc Med. 2002;156:971-974.

9. Orlow SJ, Paller A. Cimetidine Therapy For Multiple Viral Warts In Children. J Am Acad Dermatol. 1993; 28(5), 794-5.

10. Rogers CJ, Gibney MD, et. al. Cimetidine therapy for recalcitrant warts in adults: is it any better than placebo? J Am Acd Dermatol 1999; 41:123-7.

11. Stoler MH, Broker TR. In situ hybridization detection of human papillomavirus DNAs and messenger RNAs in genital condylomas and cervical carcinoma. Hum Pathol. 1986;17:1250-1258.

12. Arany I, Tyring SK. Status of local cellular immunity in interferon-responsive and -nonresponsive human papillomavirus-associated lesions. Sex Transm Dis 1996;23:475.

13. Schwartz RA. Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol. 1995;32:121.

Additional References

14. Stehr-Green PA, Hewer P, Meekin GE, et al. The aetiology and risk factors for warts among poultry processing workers. Int J Epidemiol. 1993;22:294-298.

15. Keefe M, Al-Ghamdi A, Coggon D, et al. Cutaneous warts in butchers. Br J Dermatol. 1994;130:9-14.

16. Gibbs S, Harvey I. Local treatments for cutaneous warts: systematic review. Br Medical Journal. 2002:325:461-464.

image description image description


Post new comment

  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.

More information about formatting options

Image CAPTCHA
Enter the characters shown in the image.