The Role Of MMPs In Chronic Wound Edema

By Adrianne P.S. Smith, MD, FACEP
Researchers report no qualitative differences in the expression of MMPs -1, -3, and -10 in the epidermis of chronic wounds when they compared them to normally healing wounds. However, the overall number of stromal cells expressing MMP-1 and MMP-3 are greater in chronic wounds. MMP-10 has not been detected in the dermis of chronic wounds. These studies outline the need for further research to clarify the connection between cellular expression, concentration and function of the MMPs as balanced with TIMPs. At this time, it is difficult to drawn a causal relationship between wound healing and the presence or absence of a given MMP. Dr. Smith is the Medical Director of the Wound Care Center at the Texas Diabetes Institute in San Antonio, Texas. She is an Assistant Professor in the Department of Rehabilitative Medicine at the University of Texas Health Science Center, is board-certified in emergency medicine and fellowship-trained in hyperbaric medicine. Dr. Steinberg (pictured) is an Assistant Professor in the Department of Orthopaedics/Podiatry Service at the University of Texas Health Science Center.



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Thanks a lot for publishing the above article. We surprisingly observed a unique effect on chronic wound healing as diabetic non healing ones. The events we observed were as clot formation(fibrin deposites - hemostatic phase) followed by autodebridementation of necrotic lesions compressing rejection of necrotic tisuues from the periphery to the central wound associated with ECM deposit( inflammation phase)follwoed by granulation tissue formation and wound size decrease (proliferation phase) and complete wound healing in a physiological timed manner. The cases were involved with non healing wound types of diabetes related awith and without hemodyalised states and resistant to therapy of more than 10 months up to 20 months. Our group is ready to exchange experiments and introduce our patent remedy as needed. We welcome all aspects of collaboration in mass production and research projects.
Khodaberdi Kalavi Iran, Mobile: 9111773982, Tel(home): +98 171 3351080, fax: +98 171 4423630, 2269210 Email:

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